Sandbox Reserved 958: Difference between revisions

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<StructureSection load='4NYF' size='350' side='right' caption='X-ray structure of the HIV-1 integrase catalytic core domain' scene='60/604477/Structure/1'>{{Sandbox_ESBS}}

'''Dimer of HIV-1 integrase catalytic core domain''' is the active form of the '''3'-Processing''' reaction that occurs in patients cells suffering from '''AIDS'''. The catalytic core domain is just one of three parts composing the HIV-1 integrase. This enzyme performs mainly ~~two~~ specific reactions : the '''3'-processing''' and the '''integration of the viral DNA''' into the host genome. ''In vivo'' we can find this protein in several forms such as monomer, dimers and tetramers<ref name="Dells">PMID: 19091057</ref>.

'''Dimer of HIV-1 integrase catalytic core domain''' is the active form of the '''3'-Processing''' reaction that occurs in patients cells suffering from '''AIDS'''. The catalytic core domain is just one of three parts composing the HIV-1 integrase. This enzyme performs two mainly specific reactions : the '''3'-processing''' and the '''integration of the viral DNA''' into the host genome. ''In vivo'' we can find this protein in several forms such as monomer, dimers and tetramers<ref name="Dells">PMID: 19091057</ref>.

==Biological role==

'''A'''cquired '''I'''mmune '''D'''efficiency '''S'''yndrome ('''AIDS''') is a human disease caused by the '''H'''uman '''I'''munnodeficiency '''V'''irus ('''HIV''') which is part of the retroviral virus family. This virus infects immune system's cells (Lymphocytes, Macrophages or Dendritic Cells,...) and provoke their destruction by highjacking the cellular machinery.

Sandbox Reserved 958: Difference between revisions

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 <StructureSection load='4NYF' size='350' side='right' caption='X-ray structure of the HIV-1 integrase catalytic core domain' scene='60/604477/Structure/1'>{{Sandbox_ESBS}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
-'''Dimer of HIV-1 integrase catalytic core domain''' is the active form of the '''3'-Processing''' reaction that occurs in patients cells suffering from '''AIDS'''. The catalytic core domain is just one of three parts composing the HIV-1 integrase. This enzyme performs mainly two specific reactions : the '''3'-processing''' and the '''integration of the viral DNA''' into the host genome. ''In vivo'' we can find this protein in several forms such as monomer, dimers and tetramers<ref name="Dells">PMID: 19091057</ref>.
+'''Dimer of HIV-1 integrase catalytic core domain''' is the active form of the '''3'-Processing''' reaction that occurs in patients cells suffering from '''AIDS'''. The catalytic core domain is just one of three parts composing the HIV-1 integrase. This enzyme performs two mainly  specific reactions : the '''3'-processing''' and the '''integration of the viral DNA''' into the host genome. ''In vivo'' we can find this protein in several forms such as monomer, dimers and tetramers<ref name="Dells">PMID: 19091057</ref>.
 ==Biological role==
 '''A'''cquired '''I'''mmune '''D'''efficiency '''S'''yndrome ('''AIDS''') is a human disease caused by the '''H'''uman '''I'''munnodeficiency '''V'''irus ('''HIV''') which is part of the retroviral virus family. This virus infects immune system's cells (Lymphocytes, Macrophages or Dendritic Cells,...) and provoke their destruction by highjacking the cellular machinery.