2jch: Difference between revisions

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[[Image:2jch.jpg|left|200px]]<br /><applet load="2jch" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2jch.jpg|left|200px]]
caption="2jch, resolution 2.40&Aring;" />
 
'''STRUCTURAL AND MECHANISTIC BASIS OF PENICILLIN BINDING PROTEIN INHIBITION BY LACTIVICINS'''<br />
{{Structure
|PDB= 2jch |SIZE=350|CAPTION= <scene name='initialview01'>2jch</scene>, resolution 2.40&Aring;
|SITE= <scene name='pdbsite=AC1:Pl7+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Cl+Binding+Site+For+Chain+A'>AC3</scene> and <scene name='pdbsite=AC4:Edo+Binding+Site+For+Chain+A'>AC4</scene>
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> and <scene name='pdbligand=PL7:(2E)-2-({(2S)-2-CARBOXY-2-[(PHENOXYACETYL)AMINO]ETHOXY}IMINO)PENTANEDIOIC ACID'>PL7</scene>
|ACTIVITY=
|GENE=
}}
 
'''STRUCTURAL AND MECHANISTIC BASIS OF PENICILLIN BINDING PROTEIN INHIBITION BY LACTIVICINS'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2JCH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=EDO:'>EDO</scene> and <scene name='pdbligand=PL7:'>PL7</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Pl7+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Cl+Binding+Site+For+Chain+A'>AC3</scene> and <scene name='pdbsite=AC4:Edo+Binding+Site+For+Chain+A'>AC4</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCH OCA].  
2JCH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCH OCA].  


==Reference==
==Reference==
Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins., Macheboeuf P, Fischer DS, Brown T Jr, Zervosen A, Luxen A, Joris B, Dessen A, Schofield CJ, Nat Chem Biol. 2007 Sep;3(9):565-9. Epub 2007 Aug 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17676039 17676039]
Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins., Macheboeuf P, Fischer DS, Brown T Jr, Zervosen A, Luxen A, Joris B, Dessen A, Schofield CJ, Nat Chem Biol. 2007 Sep;3(9):565-9. Epub 2007 Aug 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17676039 17676039]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Streptococcus pneumoniae r6]]
[[Category: Streptococcus pneumoniae r6]]
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[[Category: cell wall]]
[[Category: cell wall]]
[[Category: drug-binding protein]]
[[Category: drug-binding protein]]
[[Category: gamma lactam antibiotics]]
[[Category: gamma lactam antibiotic]]
[[Category: peptidoglycan]]
[[Category: peptidoglycan]]
[[Category: peptidoglycan synthesis multifunctional enzyme]]
[[Category: peptidoglycan synthesis multifunctional enzyme]]


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