4r0a: Difference between revisions
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''' | ==Crystal structure of human TLR8 in complex with uridine mononucleoside== | ||
<StructureSection load='4r0a' size='340' side='right' caption='[[4r0a]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4r0a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R0A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R0A FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r07|4r07]], [[4r08|4r08]], [[4r09|4r09]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r0a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r0a RCSB], [http://www.ebi.ac.uk/pdbsum/4r0a PDBsum]</span></td></tr> | |||
[[ | </table> | ||
[[ | == Function == | ||
[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Ohto, U]] | [[Category: Ohto, U]] | ||
[[Category: Shimizu, T]] | [[Category: Shimizu, T]] | ||
[[Category: Tanji, H]] | |||
[[Category: Antitumor drug binding]] | |||
[[Category: Antiviral binding]] | |||
[[Category: Glycosylation]] | |||
[[Category: Immune system]] | |||
[[Category: Innate immunity]] | |||
[[Category: Leucine rich repeat]] | |||
[[Category: Rna binding]] | |||
[[Category: Rna receptor]] | |||
[[Category: Rna recognition]] | |||
[[Category: Ssrna]] | |||
Revision as of 13:43, 14 January 2015
Crystal structure of human TLR8 in complex with uridine mononucleoside
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