2tmy: Difference between revisions
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==Overview== | ==Overview== | ||
The crystal structure of CheY protein from Thermotoga maritima has been, determined in four crystal forms with and without Mg++ bound, at up to 1.9, A resolution. Structural comparisons with CheY from Escherichia coli shows, substantial similarity in their folds, with some concerted changes, propagating away from the active site that suggest how phosphorylated, CheY, a signal transduction protein in bacterial chemotaxis, is recognized, by its targets. A highly conserved segment of the protein (the "y-turn, loop," residues 55-61), previously suggested to be a rigid recognition, determinant, is for the first time seen in two alternative conformations, in the different crystal structures. Although CheY from Thermotoga has, much higher thermal stability than its mesophilic counterparts, . | The crystal structure of CheY protein from Thermotoga maritima has been, determined in four crystal forms with and without Mg++ bound, at up to 1.9, A resolution. Structural comparisons with CheY from Escherichia coli shows, substantial similarity in their folds, with some concerted changes, propagating away from the active site that suggest how phosphorylated, CheY, a signal transduction protein in bacterial chemotaxis, is recognized, by its targets. A highly conserved segment of the protein (the "y-turn, loop," residues 55-61), previously suggested to be a rigid recognition, determinant, is for the first time seen in two alternative conformations, in the different crystal structures. Although CheY from Thermotoga has, much higher thermal stability than its mesophilic counterparts, comparison, of structural features previously proposed to enhance thermostability such, as hydrogen bonds, ion pairs, compactness, and hydrophobic surface burial, would not suggest it to be so. | ||
==About this Structure== | ==About this Structure== | ||
2TMY is a | 2TMY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Structure known Active Site: ACT. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2TMY OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: signal transduction]] | [[Category: signal transduction]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 13:59:47 2007'' | ||
