2jt5: Difference between revisions

[[Image:2jt5.jpg|left|200px]]<br /><applet load="2jt5" size="350" color="white" frame="true" align="right" spinBox="true"

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'''solution structure of matrix metalloproteinase 3 (MMP-3) in the presence of n-hydroxy-2-[n-(2-hydroxyethyl)biphenyl-4-sulfonamide] hydroxamic acid (MLC88)'''<br />

2JT5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=JT5:'>JT5</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] Known structural/functional Sites: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+256'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+257'>AC2</scene>, <scene name='pdbsite=AC3:Ca+Binding+Site+For+Residue+A+258'>AC3</scene>, <scene name='pdbsite=AC4:Ca+Binding+Site+For+Residue+A+259'>AC4</scene> and <scene name='pdbsite=AC5:Jt5+Binding+Site+For+Residue+A+1'>AC5</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JT5 OCA].  

Matrix metalloproteinase-inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors., Alcaraz LA, Banci L, Bertini I, Cantini F, Donaire A, Gonnelli L, J Biol Inorg Chem. 2007 Nov;12(8):1197-206. Epub 2007 Aug 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17710450 17710450]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:05:45 2008''