2kce: Difference between revisions

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[[Image:2kce.jpg|left|200px]]<br /><applet load="2kce" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2kce.jpg|left|200px]]
caption="2kce, resolution 2.2&Aring;" />
 
'''BINDING OF THE ANTICANCER DRUG ZD1694 TO E. COLI THYMIDYLATE SYNTHASE: ASSESSING SPECIFICITY AND AFFINITY'''<br />
{{Structure
|PDB= 2kce |SIZE=350|CAPTION= <scene name='initialview01'>2kce</scene>, resolution 2.2&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=UMP:2'-DEOXYURIDINE+5'-MONOPHOSPHATE'>UMP</scene> and <scene name='pdbligand=D16:TOMUDEX'>D16</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
|GENE= THYA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''BINDING OF THE ANTICANCER DRUG ZD1694 TO E. COLI THYMIDYLATE SYNTHASE: ASSESSING SPECIFICITY AND AFFINITY'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2KCE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=UMP:'>UMP</scene> and <scene name='pdbligand=D16:'>D16</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCE OCA].  
2KCE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KCE OCA].  


==Reference==
==Reference==
Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity., Rutenber EE, Stroud RM, Structure. 1996 Nov 15;4(11):1317-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8939755 8939755]
Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity., Rutenber EE, Stroud RM, Structure. 1996 Nov 15;4(11):1317-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8939755 8939755]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: reaction intermediate]]
[[Category: reaction intermediate]]


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