2nnz: Difference between revisions
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'''Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus''' | {{Structure | ||
|PDB= 2nnz |SIZE=350|CAPTION= <scene name='initialview01'>2nnz</scene> | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= AF2241 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 Archaeoglobus fulgidus]) | |||
}} | |||
'''Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2NNZ is a [ | 2NNZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNZ OCA]. | ||
==Reference== | ==Reference== | ||
Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold., Ai X, Li L, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY, J Biomol NMR. 2007 Aug;38(4):353-8. Epub 2007 Jul 4. PMID:[http:// | Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold., Ai X, Li L, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY, J Biomol NMR. 2007 Aug;38(4):353-8. Epub 2007 Jul 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17610131 17610131] | ||
[[Category: Archaeoglobus fulgidus]] | [[Category: Archaeoglobus fulgidus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: beta-barrel]] | [[Category: beta-barrel]] | ||
[[Category: ocsp]] | [[Category: ocsp]] | ||
[[Category: ontario centre for structural | [[Category: ontario centre for structural proteomic]] | ||
[[Category: structural | [[Category: structural genomic]] | ||
[[Category: unknown function]] | [[Category: unknown function]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:48:47 2008'' | ||
Revision as of 15:48, 20 March 2008
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| Gene: | AF2241 (Archaeoglobus fulgidus) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus
Overview
AF2241 is a hypothetical protein from Archaeoglobus fulgidus and it belongs to the PFam domain of unknown function 369 (DUF369). NMR structural determination reveals that AF2241 adopts a cyclophilin-like fold, with a beta-barrel core composed of eight beta-strands, one alpha-helix, and one 3(10) helix located at each end of the barrel. The protein displays a high structural similarity to TM1367, another member of DUF369 whose structure has been determined recently by X-ray crystallography. Structural similarity search shows that AF2241 also has a high similarity to human cyclophilin A, however, sequence alignment and electrostatic potential analysis reveal that the residues in the PPIase catalytic site of human cyclophilin A are not conserved in AF2241 or TM1367. Instead, a putative active site of AF2241 maps to a negatively charged pocket composed of 9 conserved residues. Our results suggest that although AF2241 adopts the same fold as the human cyclophilin A, it may have distinct biological function.
About this Structure
2NNZ is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.
Reference
Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold., Ai X, Li L, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY, J Biomol NMR. 2007 Aug;38(4):353-8. Epub 2007 Jul 4. PMID:17610131
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