2nqi: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:2nqi.gif|left|200px]]<br /><applet load="2nqi" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2nqi.gif|left|200px]]
caption="2nqi, resolution 2.04&Aring;" />
 
'''Calpain 1 proteolytic core inactivated by WR13(R,R), an epoxysuccinyl-type inhibitor.'''<br />
{{Structure
|PDB= 2nqi |SIZE=350|CAPTION= <scene name='initialview01'>2nqi</scene>, resolution 2.04&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=NQI:N~2~-[(2S)-2-{[(2R)-4-ETHOXY-2-HYDROXY-4-OXOBUTANOYL]AMINO}PENT-4-ENOYL]-L-ARGINYL-L-TRYPTOPHANAMIDE'>NQI</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Calpain-1 Calpain-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 3.4.22.52]
|GENE= Capn1, Cls1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
}}
 
'''Calpain 1 proteolytic core inactivated by WR13(R,R), an epoxysuccinyl-type inhibitor.'''
 


==Overview==
==Overview==
Line 7: Line 16:


==About this Structure==
==About this Structure==
2NQI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=NQI:'>NQI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Calpain-1 Calpain-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 3.4.22.52] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQI OCA].  
2NQI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQI OCA].  


==Reference==
==Reference==
Development of calpain-specific inactivators by screening of positional scanning epoxide libraries., Cuerrier D, Moldoveanu T, Campbell RL, Kelly J, Yoruk B, Verhelst SH, Greenbaum D, Bogyo M, Davies PL, J Biol Chem. 2007 Mar 30;282(13):9600-11. Epub 2007 Jan 11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17218315 17218315]
Development of calpain-specific inactivators by screening of positional scanning epoxide libraries., Cuerrier D, Moldoveanu T, Campbell RL, Kelly J, Yoruk B, Verhelst SH, Greenbaum D, Bogyo M, Davies PL, J Biol Chem. 2007 Mar 30;282(13):9600-11. Epub 2007 Jan 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17218315 17218315]
[[Category: Calpain-1]]
[[Category: Calpain-1]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
Line 28: Line 37:
[[Category: proteinase]]
[[Category: proteinase]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:09:44 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:49:44 2008''
Retrieved from "https://proteopedia.org/2nqi"