2nt0: Difference between revisions

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[[Image:2nt0.jpg|left|200px]]<br /><applet load="2nt0" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2nt0.jpg|left|200px]]
caption="2nt0, resolution 1.790&Aring;" />
 
'''Acid-beta-glucosidase low pH, glycerol bound'''<br />
{{Structure
|PDB= 2nt0 |SIZE=350|CAPTION= <scene name='initialview01'>2nt0</scene>, resolution 1.790&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Glucosylceramidase Glucosylceramidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.45 3.2.1.45]
|GENE= GBA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Acid-beta-glucosidase low pH, glycerol bound'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2NT0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glucosylceramidase Glucosylceramidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.45 3.2.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NT0 OCA].  
2NT0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NT0 OCA].  


==Reference==
==Reference==
Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease., Lieberman RL, Wustman BA, Huertas P, Powe AC Jr, Pine CW, Khanna R, Schlossmacher MG, Ringe D, Petsko GA, Nat Chem Biol. 2007 Feb;3(2):101-7. Epub 2006 Dec 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17187079 17187079]
Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease., Lieberman RL, Wustman BA, Huertas P, Powe AC Jr, Pine CW, Khanna R, Schlossmacher MG, Ringe D, Petsko GA, Nat Chem Biol. 2007 Feb;3(2):101-7. Epub 2006 Dec 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17187079 17187079]
[[Category: Glucosylceramidase]]
[[Category: Glucosylceramidase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: hydrolysis]]
[[Category: hydrolysis]]


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