2kmj

High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry

spinqualitylabelsall models 2kmj, 10 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2kmj is a 3 chain structure with sequence from Human immunodeficiency virus 2. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: DAR, NH2, ZUK Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Target TAR by NMR: Tripeptides containing arginines as terminal residues and non-natural amino acids as central residues are good leads for drug design to target the HIV trans-activation response element (TAR). The structural characterization of the RNA-ligand complex by NMR spectroscopy reveals two specific binding sites that are located at bulge residue U23 and around the pyrimidine-stretch U40-C41-U42 directly adjacent to the bulge. Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.,Ferner J, Suhartono M, Breitung S, Jonker HR, Hennig M, Wohnert J, Gobel M, Schwalbe H Chembiochem. 2009 Jun 15;10(9):1490-4. PMID:19444830 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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