2mdu: Difference between revisions
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==Circular Permutant of the WW Domain with Loop 1 Excised== | |||
<StructureSection load='2mdu' size='340' side='right' caption='[[2mdu]], [[NMR_Ensembles_of_Models | 22 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mdu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MDU FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pin|1pin]], [[2kcf|2kcf]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mdu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mdu RCSB], [http://www.ebi.ac.uk/pdbsum/2mdu PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A hyperstable Pin1 WW domain has been circularly permuted via excision of the fold-nucleating turn; it still folds to form the native three-strand sheet and hydrophobic core features. Multiprobe folding dynamics studies of the normal and circularly permuted sequences, as well as their constituent hairpin fragments and comparable-length beta-strand-loop-beta-strand models, indicate 2-state folding for all topologies. N-terminal hairpin formation is the fold nucleating event for the wild-type sequence; the slower folding circular permutant has a more distributed folding transition state. | |||
Circular Permutation of a WW Domain: Folding Still Occurs after Excising the Turn of the Folding-Nucleating Hairpin.,Kier BL, Anderson JM, Andersen NH J Am Chem Soc. 2014 Jan 3. PMID:24350581<ref>PMID:24350581</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
[[Category: Kier, B L | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Kier, B L]] | |||
[[Category: Circular permutation]] | [[Category: Circular permutation]] | ||
[[Category: Dynamic]] | [[Category: Dynamic]] | ||
Revision as of 15:33, 19 January 2015
Circular Permutant of the WW Domain with Loop 1 Excised
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