2o36: Difference between revisions

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[[Image:2o36.gif|left|200px]]<br /><applet load="2o36" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2o36.gif|left|200px]]
caption="2o36, resolution 1.950&Aring;" />
 
'''Crystal structure of engineered thimet oligopeptidase with neurolysin specificity in neurotensin cleavage site'''<br />
{{Structure
|PDB= 2o36 |SIZE=350|CAPTION= <scene name='initialview01'>2o36</scene>, resolution 1.950&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thimet_oligopeptidase Thimet oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.15 3.4.24.15]
|GENE= THOP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of engineered thimet oligopeptidase with neurolysin specificity in neurotensin cleavage site'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2O36 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thimet_oligopeptidase Thimet oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.15 3.4.24.15] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O36 OCA].  
2O36 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O36 OCA].  


==Reference==
==Reference==
Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase., Lim EJ, Sampath S, Coll-Rodriguez J, Schmidt J, Ray K, Rodgers DW, J Biol Chem. 2007 Mar 30;282(13):9722-32. Epub 2007 Jan 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17251185 17251185]
Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase., Lim EJ, Sampath S, Coll-Rodriguez J, Schmidt J, Ray K, Rodgers DW, J Biol Chem. 2007 Mar 30;282(13):9722-32. Epub 2007 Jan 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17251185 17251185]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: thermolysin-like domain]]
[[Category: thermolysin-like domain]]


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