2o4z: Difference between revisions

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[[Image:2o4z.gif|left|200px]]<br /><applet load="2o4z" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2o4z.gif|left|200px]]
caption="2o4z, resolution 2.10&Aring;" />
 
'''Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor'''<br />
{{Structure
|PDB= 2o4z |SIZE=350|CAPTION= <scene name='initialview01'>2o4z</scene>, resolution 2.10&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene> and <scene name='pdbligand=HSW:N-hydroxysulfamide'>HSW</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1]
|GENE=
}}
 
'''Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2O4Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=HG:'>HG</scene> and <scene name='pdbligand=HSW:'>HSW</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4Z OCA].  
2O4Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O4Z OCA].  


==Reference==
==Reference==
Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors., Temperini C, Winum JY, Montero JL, Scozzafava A, Supuran CT, Bioorg Med Chem Lett. 2007 May 15;17(10):2795-801. Epub 2007 Feb 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17346964 17346964]
Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors., Temperini C, Winum JY, Montero JL, Scozzafava A, Supuran CT, Bioorg Med Chem Lett. 2007 May 15;17(10):2795-801. Epub 2007 Feb 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17346964 17346964]
[[Category: Carbonate dehydratase]]
[[Category: Carbonate dehydratase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: carbonic anhydrase]]
[[Category: carbonic anhydrase]]
[[Category: crystal structure]]
[[Category: crystal structure]]
[[Category: inhibitors]]
[[Category: inhibitor]]


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