2vje: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vje]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJE FirstGlance]. <br> | <table><tr><td colspan='2'>[[2vje]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJE FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rv1|1rv1]], [[1t4e|1t4e]], [[1ycr|1ycr]], [[1z1m|1z1m]], [[2hdp|2hdp]], [[1t4f|1t4f]], [[2axi|2axi]], [[2c6a|2c6a]], [[2c6b|2c6b]], [[2cr8|2cr8]], [[2vjf|2vjf]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rv1|1rv1]], [[1t4e|1t4e]], [[1ycr|1ycr]], [[1z1m|1z1m]], [[2hdp|2hdp]], [[1t4f|1t4f]], [[2axi|2axi]], [[2c6a|2c6a]], [[2c6b|2c6b]], [[2cr8|2cr8]], [[2vjf|2vjf]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vje OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vje RCSB], [http://www.ebi.ac.uk/pdbsum/2vje PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vje OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vje RCSB], [http://www.ebi.ac.uk/pdbsum/2vje PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding. | [[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Day, C L | [[Category: Day, C L]] | ||
[[Category: Linke, K | [[Category: Linke, K]] | ||
[[Category: Mace, P D | [[Category: Mace, P D]] | ||
[[Category: Smith, C A | [[Category: Smith, C A]] | ||
[[Category: Host-virus interaction]] | [[Category: Host-virus interaction]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
