2wid: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wid]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WID FirstGlance]. <br> | <table><tr><td colspan='2'>[[2wid]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WID FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TUN:ETHYL+HYDROGEN+DIETHYLAMIDOPHOSPHATE'>TUN</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TUN:ETHYL+HYDROGEN+DIETHYLAMIDOPHOSPHATE'>TUN</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ehq|1ehq]], [[2j4c|2j4c]], [[1p0q|1p0q]], [[1kcj|1kcj]], [[1xlu|1xlu]], [[1p0p|1p0p]], [[1xlv|1xlv]], [[1eho|1eho]], [[1p0m|1p0m]], [[1p0i|1p0i]], [[1xlw|1xlw]], [[2wik|2wik]], [[2wif|2wif]], [[2wij|2wij]], [[2wig|2wig]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ehq|1ehq]], [[2j4c|2j4c]], [[1p0q|1p0q]], [[1kcj|1kcj]], [[1xlu|1xlu]], [[1p0p|1p0p]], [[1xlv|1xlv]], [[1eho|1eho]], [[1p0m|1p0m]], [[1p0i|1p0i]], [[1xlw|1xlw]], [[2wik|2wik]], [[2wif|2wif]], [[2wij|2wij]], [[2wig|2wig]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wid RCSB], [http://www.ebi.ac.uk/pdbsum/2wid PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wid RCSB], [http://www.ebi.ac.uk/pdbsum/2wid PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. | [[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. | ||
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[[Category: Cholinesterase]] | [[Category: Cholinesterase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Aurbek, N | [[Category: Aurbek, N]] | ||
[[Category: Carletti, E | [[Category: Carletti, E]] | ||
[[Category: Fontecilla, J | [[Category: Fontecilla, J]] | ||
[[Category: Gillon, E | [[Category: Gillon, E]] | ||
[[Category: Loiodice, M | [[Category: Loiodice, M]] | ||
[[Category: Masson, P | [[Category: Masson, P]] | ||
[[Category: Nachon, F | [[Category: Nachon, F]] | ||
[[Category: Nicolet, Y | [[Category: Nicolet, Y]] | ||
[[Category: Thiermann, H | [[Category: Thiermann, H]] | ||
[[Category: Worek, F | [[Category: Worek, F]] | ||
[[Category: Aging]] | [[Category: Aging]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
