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[[Image:333d.png|left|200px]]
==THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES==
<StructureSection load='333d' size='340' side='right' caption='[[333d]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[333d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=333D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=333D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=I:INOSINIC+ACID'>I</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=333d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=333d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=333d RCSB], [http://www.ebi.ac.uk/pdbsum/333d PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The X-ray crystallographic structure of the RNA duplex [r(CGCAIGCG)]2 has been refined to 2.5 A. It shows a symmetric internal loop of two non-Watson-Crick base pairs which form in the middle of the duplex. The tandem A-I/I-A pairs are related by a crystallographic two-fold axis. Both A(anti)-I(anti) mismatches are in a head-to-head conformation forming hydrogen bonds using the Watson-Crick positions. The octamer duplexes stack above one another in the cell forming a pseudo-infinite helix throughout the crystal. A hydrated calcium ion bridges between the 3'-terminal of one molecule and the backbone of another. The tandem A-I mismatches are incorporated with only minor distortion to the backbone. This is in contrast to the large helical perturbations often produced by sheared G-A pairs in RNA oligonucleotides.


{{STRUCTURE_333d|  PDB=333d  |  SCENE=  }}
The crystal structure of an RNA oligomer incorporating tandem adenosine-inosine mismatches.,Carter RJ, Baeyens KJ, SantaLucia J, Turner DH, Holbrook SR Nucleic Acids Res. 1997 Oct 15;25(20):4117-22. PMID:9321667<ref>PMID:9321667</ref>


===THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_9321667}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[333d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=333D OCA].
</StructureSection>
[[Category: Baeyens, K J.]]
[[Category: Baeyens, K J]]
[[Category: Carter, R J.]]
[[Category: Carter, R J]]
[[Category: Holbrook, S R.]]
[[Category: Holbrook, S R]]
[[Category: SantaLucia, J.]]
[[Category: SantaLucia, J]]
[[Category: Turner, D H.]]
[[Category: Turner, D H]]
[[Category: A-rna]]
[[Category: A-rna]]
[[Category: Double helix]]
[[Category: Double helix]]
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