4qdh

Crystal Structure of the C-terminal Domain of Mouse TLR9

spinqualitylabelsall models 4qdh, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4qdh is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NAG, SO4 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Toll-like receptors (TLRs) are important pattern recognition receptors that function in innate immunity. Elucidating the structure and signaling mechanisms of TLR9, a sensor of foreign and endogenous DNA, is essential for understanding its key role in immunity against microbial pathogens as well as in autoimmunity. Abundant evidence suggests that the TLR9-CTD (C-terminal domain) by itself is capable of DNA binding and signaling. The crystal structure of unliganded mouse TLR9-CTD is presented. TLR9-CTD exhibits one unique feature, a cluster of stacked aromatic and arginine side chains on its concave face. Overall, its structure is most related to the TLR8-CTD, suggesting a similar mode of ligand binding and signaling. Proteins 2014;. (c) 2014 Wiley Periodicals, Inc. Crystal structure of the C-terminal domain of mouse TLR9.,Collins B, Wilson IA Proteins. 2014 May 30. doi: 10.1002/prot.24616. PMID:24888966 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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