2oow: Difference between revisions

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[[Image:2oow.jpg|left|200px]]<br /><applet load="2oow" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2oow.jpg|left|200px]]
caption="2oow, resolution 1.750&Aring;" />
 
'''MIF Bound to a Fluorinated OXIM Derivative'''<br />
{{Structure
|PDB= 2oow |SIZE=350|CAPTION= <scene name='initialview01'>2oow</scene>, resolution 1.750&Aring;
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+901'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+B+902'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+C+903'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+A+904'>AC4</scene>, <scene name='pdbsite=AC5:So4+Binding+Site+For+Residue+C+905'>AC5</scene>, <scene name='pdbsite=AC6:Ox4+Binding+Site+For+Residue+A+200'>AC6</scene>, <scene name='pdbsite=AC7:Ox4+Binding+Site+For+Residue+C+200'>AC7</scene>, <scene name='pdbsite=AC8:Gol+Binding+Site+For+Residue+A+701'>AC8</scene>, <scene name='pdbsite=AC9:Gol+Binding+Site+For+Residue+B+702'>AC9</scene>, <scene name='pdbsite=BC1:Gol+Binding+Site+For+Residue+C+703'>BC1</scene>, <scene name='pdbsite=BC2:Gol+Binding+Site+For+Residue+A+704'>BC2</scene>, <scene name='pdbsite=BC3:Gol+Binding+Site+For+Residue+C+705'>BC3</scene>, <scene name='pdbsite=BC4:Gol+Binding+Site+For+Residue+A+706'>BC4</scene>, <scene name='pdbsite=BC5:Ipa+Binding+Site+For+Residue+C+801'>BC5</scene>, <scene name='pdbsite=BC6:Ipa+Binding+Site+For+Residue+C+802'>BC6</scene> and <scene name='pdbsite=BC7:Ipa+Binding+Site+For+Residue+C+803'>BC7</scene>
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=OX4:3-FLUORO-4-HYDROXYBENZALDEHYDE+O-(CYCLOHEXYLCARBONYL)OXIME'>OX4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> and <scene name='pdbligand=IPA:ISOPROPYL ALCOHOL'>IPA</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phenylpyruvate_tautomerase Phenylpyruvate tautomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.2.1 5.3.2.1]
|GENE= MIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''MIF Bound to a Fluorinated OXIM Derivative'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2OOW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=OX4:'>OX4</scene>, <scene name='pdbligand=GOL:'>GOL</scene> and <scene name='pdbligand=IPA:'>IPA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phenylpyruvate_tautomerase Phenylpyruvate tautomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.2.1 5.3.2.1] Known structural/functional Sites: <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+901'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+B+902'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+C+903'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+A+904'>AC4</scene>, <scene name='pdbsite=AC5:So4+Binding+Site+For+Residue+C+905'>AC5</scene>, <scene name='pdbsite=AC6:Ox4+Binding+Site+For+Residue+A+200'>AC6</scene>, <scene name='pdbsite=AC7:Ox4+Binding+Site+For+Residue+C+200'>AC7</scene>, <scene name='pdbsite=AC8:Gol+Binding+Site+For+Residue+A+701'>AC8</scene>, <scene name='pdbsite=AC9:Gol+Binding+Site+For+Residue+B+702'>AC9</scene>, <scene name='pdbsite=BC1:Gol+Binding+Site+For+Residue+C+703'>BC1</scene>, <scene name='pdbsite=BC2:Gol+Binding+Site+For+Residue+A+704'>BC2</scene>, <scene name='pdbsite=BC3:Gol+Binding+Site+For+Residue+C+705'>BC3</scene>, <scene name='pdbsite=BC4:Gol+Binding+Site+For+Residue+A+706'>BC4</scene>, <scene name='pdbsite=BC5:Ipa+Binding+Site+For+Residue+C+801'>BC5</scene>, <scene name='pdbsite=BC6:Ipa+Binding+Site+For+Residue+C+802'>BC6</scene> and <scene name='pdbsite=BC7:Ipa+Binding+Site+For+Residue+C+803'>BC7</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOW OCA].  
2OOW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OOW OCA].  


==Reference==
==Reference==
Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor., Crichlow GV, Cheng KF, Dabideen D, Ochani M, Aljabari B, Pavlov VA, Miller EJ, Lolis E, Al-Abed Y, J Biol Chem. 2007 Aug 10;282(32):23089-95. Epub 2007 May 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17526494 17526494]
Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor., Crichlow GV, Cheng KF, Dabideen D, Ochani M, Aljabari B, Pavlov VA, Miller EJ, Lolis E, Al-Abed Y, J Biol Chem. 2007 Aug 10;282(32):23089-95. Epub 2007 May 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17526494 17526494]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phenylpyruvate tautomerase]]
[[Category: Phenylpyruvate tautomerase]]
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[[Category: OX4]]
[[Category: OX4]]
[[Category: SO4]]
[[Category: SO4]]
[[Category: alternative ligand-binding modes]]
[[Category: alternative ligand-binding mode]]
[[Category: isomerase]]
[[Category: isomerase]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:20:52 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:02:36 2008''
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