4lrj

Bacterial Effector NleH1 Kinase Domain with AMPPNP and Mg2+

spinqualitylabelsall models 4lrj, resolution 1.62Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4lrj is a 2 chain structure with sequence from Eco57. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ANP, MG Related: 4lrk Gene: ECs0848, nleh1, Z0989 (ECO57) Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Upon host cell infection, pathogenic Escherichia coli hijacks host cellular processes with the help of 20-60 secreted effector proteins that subvert cellular processes to create an environment conducive to bacterial survival. The NleH effector kinases manipulate the NF-kappaB pathway and prevent apoptosis. They show low sequence similarity to human regulatory kinases and contain two domains, the N-terminal, likely intrinsically unfolded, and a C-terminal kinase-like domain. We show that these effectors autophosphorylate on sites located predominantly in the N-terminal segment. The kinase domain displays a minimal kinase fold, but lacks an activation loop and the GHI subdomain. Nevertheless, all catalytically important residues are conserved. ATP binding proceeds with minimal structural rearrangements. The NleH structure is the first for the bacterial effector kinases family. NleHs and their homologous effector kinases form a new kinase family within the cluster of eukaryotic-like kinases that includes also Rio, Bud32, and KdoK families. NleH Defines a New Family of Bacterial Effector Kinases.,Grishin AM, Cherney M, Anderson DH, Phanse S, Babu M, Cygler M Structure. 2013 Dec 24. pii: S0969-2126(13)00456-5. doi:, 10.1016/j.str.2013.11.006. PMID:24373767 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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