2ot8: Difference between revisions
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[[Image:2ot8.gif|left|200px]] | [[Image:2ot8.gif|left|200px]] | ||
'''Karyopherin Beta2/Transportin-hnRNPM NLS Complex''' | {{Structure | ||
|PDB= 2ot8 |SIZE=350|CAPTION= <scene name='initialview01'>2ot8</scene>, resolution 3.1Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= TNPO1, KPNB2, MIP1, TRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), HNRPM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Karyopherin Beta2/Transportin-hnRNPM NLS Complex''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2OT8 is a [ | 2OT8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OT8 OCA]. | ||
==Reference== | ==Reference== | ||
Structure-based design of a pathway-specific nuclear import inhibitor., Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM, Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:[http:// | Structure-based design of a pathway-specific nuclear import inhibitor., Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM, Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17435768 17435768] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: nuclear import complex]] | [[Category: nuclear import complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:04:10 2008'' | ||
Revision as of 16:04, 20 March 2008
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| 2ot8, resolution 3.1Å | |||||||||||||
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| Gene: | TNPO1, KPNB2, MIP1, TRN (Homo sapiens), HNRPM (Homo sapiens) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Karyopherin Beta2/Transportin-hnRNPM NLS Complex
Overview
Kapbeta2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only at consensus motifs, which explains ligand diversity. On the basis of these data and complementary biochemical analyses, we designed a Kapbeta2-specific nuclear import inhibitor, M9M.
Disease
Known disease associated with this structure: Deafness, mitochondrial, modifier of OMIM:[610230]
About this Structure
2OT8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure-based design of a pathway-specific nuclear import inhibitor., Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM, Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:17435768
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