4wg0: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of a tridecameric superhelix==

~~The entry~~ 4wg0 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4wg0]] is a 13 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WG0 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WG0 FirstGlance].

~~Authors~~: ~~Rudolph~~, M.G., ~~Uson~~, I., ~~Schoch~~, G.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>

~~Description~~:

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wg0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wg0 RCSB], [http://www.ebi.ac.uk/pdbsum/4wg0 PDBsum]</td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.

== Function ==

[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Rudolph, M G]]

[[Category: Schoch, G]]

[[Category: Uson, I]]

[[Category: ~~Rudolph, M.G~~]]

[[Category: Arcimboldo molecular replacement]]

[[Category: ~~Schoch, G~~]]

[[Category: Glucocorticoid receptor]]

[[Category: Superhelix]]

[[Category: Tif2 co-activator peptide]]

[[Category: Transcription]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of a tridecameric superhelix==
+<StructureSection load='4wg0' size='340' side='right' caption='[[4wg0]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
-The entry 4wg0 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4wg0]] is a 13 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WG0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WG0 FirstGlance]. <br>
-Authors: Rudolph, M.G., Uson, I., Schoch, G.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-Description:
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wg0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wg0 RCSB], [http://www.ebi.ac.uk/pdbsum/4wg0 PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
+== Function ==
+[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Rudolph, M G]]
+[[Category: Schoch, G]]
 [[Category: Uson, I]]
-[[Category: Rudolph, M.G]]
+[[Category: Arcimboldo molecular replacement]]
-[[Category: Schoch, G]]
+[[Category: Glucocorticoid receptor]]
+[[Category: Superhelix]]
+[[Category: Tif2 co-activator peptide]]
+[[Category: Transcription]]