2o4f

Structure of a parallel-stranded guanine tetraplex crystallised with monovalent ions

spinqualitylabelsall models 2o4f, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2o4f is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: LI, NA Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed A parallel 5'-d(TGGGGT)-3' quadruplex was formed in Na(+) solution and crystallized using lithium sulfate as the main precipitating agent. The X-ray structure was determined to 1.5 A resolution in space group P2(1) by molecular replacement. The asymmetric unit consists of a characteristic motif of two quadruplexes stacked at their 5' ends. All nucleotides are clearly defined in the density and could be positioned. A single bound Li(+) ion is observed at the surface of the column formed by the two joined molecules. Thus, this small alkali metal ion appears to be unsuitable as a replacement for the Na(+) ion in the central channel of G-quartets, unlike K(+) or Tl(+) ions. A well conserved constellation of water molecules is observed in the grooves of the dimeric structure. Structure of a d(TGGGGT) quadruplex crystallized in the presence of Li+ ions.,Creze C, Rinaldi B, Haser R, Bouvet P, Gouet P Acta Crystallogr D Biol Crystallogr. 2007 Jun;63(Pt 6):682-8. Epub 2007, May 15. PMID:17505106 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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