2lze

Ligase 10C

spinqualitylabelsall models 2lze, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2lze is a 1 chain structure with sequence from Synthetic construct. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ZN Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Engineering functional protein scaffolds capable of carrying out chemical catalysis is a major challenge in enzyme design. Starting from a noncatalytic protein scaffold, we recently generated a new RNA ligase by in vitro directed evolution. This artificial enzyme lost its original fold and adopted an entirely new structure with substantially enhanced conformational dynamics, demonstrating that a primordial fold with suitable flexibility is sufficient to carry out enzymatic function. Structure and dynamics of a primordial catalytic fold generated by in vitro evolution.,Chao FA, Morelli A, Iii JC, Churchfield L, Hagmann LN, Shi L, Masterson LR, Sarangi R, Veglia G, Seelig B Nat Chem Biol. 2012 Dec 9. doi: 10.1038/nchembio.1138. PMID:23222886 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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