Antimicrobial peptides: Difference between revisions
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• LL37 from human - In water, it exhibits a circular dichroism (CD) spectrum that is consistent with a disordered structure.However, in 15 mM HCO3–, SO42– or CF3CO2–, the peptide adopts a helical structure. | • LL37 from human - In water, it exhibits a circular dichroism (CD) spectrum that is consistent with a disordered structure.However, in 15 mM HCO3–, SO42– or CF3CO2–, the peptide adopts a helical structure. | ||
(3) Cationic peptides enriched for specific amino acids - contains ~44 cationic peptides that are rich in certain amino acids. These peptides lack cysteine residues and are linear, although some can form extended coilsץ | |||
'''(3) Cationic peptides enriched for specific amino acids''' - contains ~44 cationic peptides that are rich in certain amino acids. These peptides lack cysteine residues and are linear, although some can form extended coilsץ | |||
• Proline-containing peptides include abaecin from honeybees. | • Proline-containing peptides include abaecin from honeybees. | ||
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• Tryptophan-containing peptides include indolicidin from cattle. | • Tryptophan-containing peptides include indolicidin from cattle. | ||
• Small histidine-rich salivary polypeptides, including the histatins from man and some higher primates116. | • Small histidine-rich salivary polypeptides, including the histatins from man and some higher primates116. | ||
(4)''' Anionic and cationic peptides that contain cysteine and form disulphide bonds''' - this group has ~380 members, contain cysteine residues and form disulphide bonds and stable β-sheets. | (4)''' Anionic and cationic peptides that contain cysteine and form disulphide bonds''' - this group has ~380 members, contain cysteine residues and form disulphide bonds and stable β-sheets. | ||
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• Peptides with >3 disulphide bonds include drosomycin in fruit flies and plant antifungal defensins. | • Peptides with >3 disulphide bonds include drosomycin in fruit flies and plant antifungal defensins. | ||
'''(5) Anionic and cationic peptide fragments of larger proteins''' - these fragments have antimicrobial activity and are similar in composition and structure to the antimicrobial peptides described above. However, their role in innate immunity is not yet clear. | '''(5) Anionic and cationic peptide fragments of larger proteins''' - these fragments have antimicrobial activity and are similar in composition and structure to the antimicrobial peptides described above. However, their role in innate immunity is not yet clear. | ||
