Antimicrobial peptides: Difference between revisions
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(4)''' Anionic and cationic peptides that contain cysteine and form disulphide bonds''' - this group has ~380 members, contain cysteine residues and form disulphide bonds and stable β-sheets. | (4)''' Anionic and cationic peptides that contain cysteine and form disulphide bonds''' - this group has ~380 members, contain cysteine residues and form disulphide bonds and stable β-sheets. | ||
A diverse family of defensins is belong to this group. | A diverse family of defensins ([[defensin]] in proteopeia) is belong to this group. | ||
There are ~55 α-defensins, which include human neutrophil peptides (HNPs) and cryptdins and comprise | There are ~55 α-defensins, which include human neutrophil peptides (HNPs) and cryptdins and comprise | ||
29–35 amino acid residues, including six cysteines that are linked by three intramolecular disulphide bonds. | 29–35 amino acid residues, including six cysteines that are linked by three intramolecular disulphide bonds. | ||
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'''(5) Anionic and cationic peptide fragments of larger proteins''' - these fragments have antimicrobial activity and are similar in composition and structure to the antimicrobial peptides described above. However, their role in innate immunity is not yet clear. | '''(5) Anionic and cationic peptide fragments of larger proteins''' - these fragments have antimicrobial activity and are similar in composition and structure to the antimicrobial peptides described above. However, their role in innate immunity is not yet clear. | ||
• Lactoferricin from lactoferrin (human lactoferrin in proteopedia | • Lactoferricin from lactoferrin ([[human lactoferrin]] in proteopedia). | ||
• Casocidin I from human casein. | • Casocidin I from human casein. | ||
• Antimicrobial domains from bovine α-lactalbumin, human haemoglobin, lysozyme and ovalbumin. | • Antimicrobial domains from bovine α-lactalbumin, human haemoglobin [[Hen Egg-White (HEW) Lysozyme]], lysozyme and ovalbumin. | ||
