Magainin 2: Difference between revisions

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==Crystalization of Ala-Magainin==  
==Crystalization of Ala-Magainin==  
So far we had shown Magainin 2 structure based only on NMR findings, since it is very hard to perform crystalization of peptides.  
So far we had shown Magainin 2 structure based only on NMR findings, Because helical AMPs crystallography is limited, since it is hard to form crystals.
In the Hypuka et al., 2013, In order to perform crystallization of Magainin 2, changes in the sequence were maid, and Ala-Magainin 2 was contsructed. In Ala-magainin one Ser (S) and two Gly (G) residues have been changed to Ala (A) in order to increase helical propensity.