2p3g: Difference between revisions

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[[Image:2p3g.jpg|left|200px]]<br /><applet load="2p3g" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2p3g.jpg|left|200px]]
caption="2p3g, resolution 3.800&Aring;" />
 
'''Crystal structure of a pyrrolopyridine inhibitor bound to MAPKAP Kinase-2'''<br />
{{Structure
|PDB= 2p3g |SIZE=350|CAPTION= <scene name='initialview01'>2p3g</scene>, resolution 3.800&Aring;
|SITE= <scene name='pdbsite=AC1:F10+Binding+Site+For+Residue+X+401'>AC1</scene>
|LIGAND= <scene name='pdbligand=F10:2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE'>F10</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]
|GENE= MAPKAPK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of a pyrrolopyridine inhibitor bound to MAPKAP Kinase-2'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2P3G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=F10:'>F10</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P3G OCA].  
2P3G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P3G OCA].  


==Reference==
==Reference==
Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)., Anderson DR, Meyers MJ, Vernier WF, Mahoney MW, Kurumbail RG, Caspers N, Poda GI, Schindler JF, Reitz DB, Mourey RJ, J Med Chem. 2007 May 31;50(11):2647-54. Epub 2007 May 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17480064 17480064]
Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)., Anderson DR, Meyers MJ, Vernier WF, Mahoney MW, Kurumbail RG, Caspers N, Poda GI, Schindler JF, Reitz DB, Mourey RJ, J Med Chem. 2007 May 31;50(11):2647-54. Epub 2007 May 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17480064 17480064]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: atp-binding]]
[[Category: atp-binding]]
[[Category: kinase domain]]
[[Category: kinase domain]]
[[Category: map kinases]]
[[Category: map kinase]]
[[Category: mk-2]]
[[Category: mk-2]]
[[Category: mk2]]
[[Category: mk2]]
[[Category: serine/threonine kinase]]
[[Category: serine/threonine kinase]]
[[Category: transferase]]


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