2kqg

A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics

spinqualitylabelsall models 2kqg, 10 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2kqg is a 1 chain structure. This structure supersedes the now removed PDB entry 2kj0. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: K Related: 2kqh Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Guanine-rich DNA sequences with the ability to form quadruplex structures are enriched in the promoter regions of protein-coding genes, particularly those of proto-oncogenes. G-quadruplexes are structurally polymorphic and their folding topologies can depend on the sample conditions. We report here on a structural study using solution state NMR spectroscopy of a second G-quadruplex-forming motif (c-kit2) that has been recently identified in the promoter region of the c-kit oncogene. In the presence of potassium ions, c-kit2 exists as an ensemble of structures that share the same parallel-stranded propeller-type conformations. Subtle differences in structural dynamics have been identified using hydrogen-deuterium exchange experiments by NMR spectroscopy, suggesting the coexistence of at least two structurally similar but dynamically distinct substates, which undergo slow interconversion on the NMR timescale. A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.,Hsu ST, Varnai P, Bugaut A, Reszka AP, Neidle S, Balasubramanian S J Am Chem Soc. 2009 Sep 23;131(37):13399-409. PMID:19705869 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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