Odorant binding protein: Difference between revisions

====Protein conformations====

[[Image:A -B forms without ligand.png|thumb|upright=2|The A and B forms without ligand (PDB IDs: [[1gm0]] and [[1ls8]]).]]

BmorPBP has two conformations: The '''"closed form" (A)''' and the ''"open form" (B)''<ref>DOI: 10.1074/jbc.274.43.30950</ref>. The bombykol and the alpha-helix loacated in the c-terminus of the protein compete for the binding site: when the c-terminus is inside the binding cavity it get's an alpha helix shape, and the protien is in its "close form" (B), whereas in the "open form" (A) the c-terminus is outside of the protein and has no defined secondary structure. Binding experiments have shown that the B-form binds 15 times higher than the A-form <ref>doi: 10.1073/pnas.0501447102</ref>, therefore considered to be the carrier of the pheromone. The complex of the A-form and the pheromone, is then considered the form that activates the receptor.