2pbi: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:2pbi.jpg|left|200px]]<br /><applet load="2pbi" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2pbi.jpg|left|200px]]
caption="2pbi, resolution 1.950&Aring;" />
 
'''The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure'''<br />
{{Structure
|PDB= 2pbi |SIZE=350|CAPTION= <scene name='initialview01'>2pbi</scene>, resolution 1.950&Aring;
|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Residue+D+901'>AC1</scene>, <scene name='pdbsite=AC2:Gol+Binding+Site+For+Residue+B+902'>AC2</scene>, <scene name='pdbsite=AC3:Gol+Binding+Site+For+Residue+D+903'>AC3</scene>, <scene name='pdbsite=AC4:Gol+Binding+Site+For+Residue+A+904'>AC4</scene>, <scene name='pdbsite=AC5:Gol+Binding+Site+For+Residue+A+905'>AC5</scene>, <scene name='pdbsite=AC6:Gol+Binding+Site+For+Residue+A+906'>AC6</scene>, <scene name='pdbsite=AC7:Gol+Binding+Site+For+Residue+C+907'>AC7</scene>, <scene name='pdbsite=AC8:Gol+Binding+Site+For+Residue+D+908'>AC8</scene> and <scene name='pdbsite=AC9:Gol+Binding+Site+For+Residue+B+909'>AC9</scene>
|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY=
|GENE= Rgs9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Gnb5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
}}
 
'''The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure'''
 


==Overview==
==Overview==
Line 7: Line 16:


==About this Structure==
==About this Structure==
2PBI is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=AC1:Gol+Binding+Site+For+Residue+D+901'>AC1</scene>, <scene name='pdbsite=AC2:Gol+Binding+Site+For+Residue+B+902'>AC2</scene>, <scene name='pdbsite=AC3:Gol+Binding+Site+For+Residue+D+903'>AC3</scene>, <scene name='pdbsite=AC4:Gol+Binding+Site+For+Residue+A+904'>AC4</scene>, <scene name='pdbsite=AC5:Gol+Binding+Site+For+Residue+A+905'>AC5</scene>, <scene name='pdbsite=AC6:Gol+Binding+Site+For+Residue+A+906'>AC6</scene>, <scene name='pdbsite=AC7:Gol+Binding+Site+For+Residue+C+907'>AC7</scene>, <scene name='pdbsite=AC8:Gol+Binding+Site+For+Residue+D+908'>AC8</scene> and <scene name='pdbsite=AC9:Gol+Binding+Site+For+Residue+B+909'>AC9</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PBI OCA].  
2PBI is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PBI OCA].  


==Reference==
==Reference==
Crystal structure of the multifunctional Gbeta5-RGS9 complex., Cheever ML, Snyder JT, Gershburg S, Siderovski DP, Harden TK, Sondek J, Nat Struct Mol Biol. 2008 Feb;15(2):155-62. Epub 2008 Jan 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18204463 18204463]
Crystal structure of the multifunctional Gbeta5-RGS9 complex., Cheever ML, Snyder JT, Gershburg S, Siderovski DP, Harden TK, Sondek J, Nat Struct Mol Biol. 2008 Feb;15(2):155-62. Epub 2008 Jan 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18204463 18204463]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
Line 28: Line 37:
[[Category: signaling protein]]
[[Category: signaling protein]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:27:54 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:11:10 2008''

Revision as of 16:11, 20 March 2008

File:2pbi.jpg


Drag the structure with the mouse to rotate
2pbi, resolution 1.950Å
Sites: AC1, AC2, AC3, AC4, AC5, AC6, AC7, AC8 and AC9
Ligands: GOL
Gene: Rgs9 (Mus musculus), Gnb5 (Mus musculus)
Coordinates: save as pdb, mmCIF, xml



The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure


Overview

Regulators of G-protein signaling (RGS) proteins enhance the intrinsic GTPase activity of G protein alpha (Galpha) subunits and are vital for proper signaling kinetics downstream of G protein-coupled receptors (GPCRs). R7 subfamily RGS proteins specifically and obligately dimerize with the atypical G protein beta5 (Gbeta5) subunit through an internal G protein gamma (Ggamma)-subunit-like (GGL) domain. Here we present the 1.95-A crystal structure of the Gbeta5-RGS9 complex, which is essential for normal visual and neuronal signal transduction. This structure reveals a canonical RGS domain that is functionally integrated within a molecular complex that is poised for integration of multiple steps during G-protein activation and deactivation.

About this Structure

2PBI is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the multifunctional Gbeta5-RGS9 complex., Cheever ML, Snyder JT, Gershburg S, Siderovski DP, Harden TK, Sondek J, Nat Struct Mol Biol. 2008 Feb;15(2):155-62. Epub 2008 Jan 20. PMID:18204463

Page seeded by OCA on Thu Mar 20 18:11:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2pbi&oldid=236882"