4rxj: Difference between revisions
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''' | ==crytal structure of WHSC1L1-PWWP2== | ||
<StructureSection load='4rxj' size='340' side='right' caption='[[4rxj]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4rxj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RXJ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rxj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rxj RCSB], [http://www.ebi.ac.uk/pdbsum/4rxj PDBsum]</span></td></tr> | |||
[[Category: | </table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Histone-lysine N-methyltransferase]] | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | |||
[[Category: Dong, A]] | [[Category: Dong, A]] | ||
[[Category: | [[Category: Edwards, A M]] | ||
[[Category: Li, Y]] | [[Category: Li, Y]] | ||
[[Category: Min, J]] | [[Category: Min, J]] | ||
[[Category: | [[Category: Qin, S]] | ||
[[Category: Structural genomic]] | |||
[[Category: Tempel, W]] | [[Category: Tempel, W]] | ||
[[Category: | [[Category: Sgc]] | ||
[[Category: | [[Category: Transferase]] | ||
Revision as of 16:47, 28 January 2015
crytal structure of WHSC1L1-PWWP2
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