Antimicrobial peptides: Difference between revisions

1- barrel stave pore model ,that claims peptides interact laterally with one another to form a specific structure enclosing a water-filled channel, much like a protein ion channel.  

[[Image:Barrel stave pore model.JPG]]

2- toroidal pore model, that claims specific peptide–peptide interactions are not present, and instead, single peptides are bound to the membrane’s phospholipids and disturbe it’s structure..

the Nonepore model claims peptides bind to the membrane until it collapses. It is devided into 2 main mechanisms:

1- The carpet model. In this model, antimicrobial peptides accumulate on the membrane surface with an orientation that is parallel to the membrane.When peptide concentration has reached a critical level permeabilization occurs via global bilayer destabilization.

2- detergent model-  collapse of membrane integrity, observed with some AMPs at high peptide concentration.