Antimicrobial peptides: Difference between revisions

In the Transmembrane Pore Models, it is suggested that AMPs form many pores in the mambrane, so that it cannot hold it's content anymore.  

The''' transmembrane pore mechanism''' has 2 main models:  

'''1- barrel stave pore model''' ,that claims peptides interact laterally with one another to form a specific structure enclosing a water-filled channel, much like a protein ion channel.  

[[Image:Barrel stave pore model.JPG]]

the '''Nonepore model''' claims peptides bind to the membrane until it collapses. It is devided into 2 main mechanisms:

'''1- The carpet model''': In this model, antimicrobial peptides accumulate on the membrane surface with an orientation that is parallel to the membrane.When peptide concentration has reached a critical level permeabilization occurs via global bilayer destabilization.

'''2- detergent model''' : collapse of membrane integrity, observed with some AMPs at high peptide concentration.

[[Image:Detergent model.JPG]]