2pk5: Difference between revisions

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[[Image:2pk5.jpg|left|200px]]~~<br /><applet load~~="2pk5~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:2pk5.jpg|left|200px]]

~~caption="~~2pk5, resolution 1.900Å" />

'''Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I ) in Complex with KNI-10075'''~~<br />~~

{{Structure

|PDB= 2pk5 |SIZE=350|CAPTION= <scene name='initialview01'>2pk5</scene>, resolution 1.900Å

|SITE=

|LIGAND= <scene name='pdbligand=075:(4R)-N-[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]-3-[(2S,3S)-2-HYDROXY-3-{[(2R)-2-{[(ISOQUINOLIN-5-YLOXY)ACETYL]AMINO}-3-(METHYLSULFONYL)PROPANOYL]AMINO}-4-PHENYLBUTANOYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>075</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>

|ACTIVITY=

|GENE= gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])

}}

'''Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I ) in Complex with KNI-10075'''

==Overview==

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==About this Structure==

2PK5 is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1~~] with <scene name='pdbligand=075:'>075</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PK5 OCA].

2PK5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PK5 OCA].

==Reference==

Compensating enthalpic and entropic changes hinder binding affinity optimization., Lafont V, Armstrong AA, Ohtaka H, Kiso Y, Mario Amzel L, Freire E, Chem Biol Drug Des. 2007 Jun;69(6):413-22. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~17581235 17581235]

Compensating enthalpic and entropic changes hinder binding affinity optimization., Lafont V, Armstrong AA, Ohtaka H, Kiso Y, Mario Amzel L, Freire E, Chem Biol Drug Des. 2007 Jun;69(6):413-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17581235 17581235]

[[Category: Human immunodeficiency virus 1]]

[[Category: Single protein]]

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[[Category: protease complex]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:13:59 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2pk5.jpg|left|200px]]<br /><applet load="2pk5" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2pk5.jpg|left|200px]]
-caption="2pk5, resolution 1.900&Aring;" />
-'''Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I ) in Complex with KNI-10075'''<br />
+ {{Structure
+|PDB= 2pk5 |SIZE=350|CAPTION= <scene name='initialview01'>2pk5</scene>, resolution 1.900&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=075:(4R)-N-[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]-3-[(2S,3S)-2-HYDROXY-3-{[(2R)-2-{[(ISOQUINOLIN-5-YLOXY)ACETYL]AMINO}-3-(METHYLSULFONYL)PROPANOYL]AMINO}-4-PHENYLBUTANOYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXAMIDE'>075</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
+|ACTIVITY=
+|GENE= gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
+}}
+'''Crystal Structure of HIV-1 Protease (Q7K, L33I, L63I ) in Complex with KNI-10075'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-PK5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=075:'>075</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PK5 OCA].
+PK5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PK5 OCA].
 ==Reference==
-Compensating enthalpic and entropic changes hinder binding affinity optimization., Lafont V, Armstrong AA, Ohtaka H, Kiso Y, Mario Amzel L, Freire E, Chem Biol Drug Des. 2007 Jun;69(6):413-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17581235 17581235]
+Compensating enthalpic and entropic changes hinder binding affinity optimization., Lafont V, Armstrong AA, Ohtaka H, Kiso Y, Mario Amzel L, Freire E, Chem Biol Drug Des. 2007 Jun;69(6):413-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17581235 17581235]
 [[Category: Human immunodeficiency virus 1]]
 [[Category: Single protein]]
@@ Line 22: / Line 31: @@
 [[Category: protease complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:30:21 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:13:59 2008''