2pnu: Difference between revisions

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[[Image:2pnu.jpg|left|200px]]<br /><applet load="2pnu" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2pnu.jpg|left|200px]]
caption="2pnu, resolution 1.650&Aring;" />
 
'''Crystal structure of human androgen receptor ligand-binding domain in complex with EM-5744'''<br />
{{Structure
|PDB= 2pnu |SIZE=350|CAPTION= <scene name='initialview01'>2pnu</scene>, resolution 1.650&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ENM:(5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE'>ENM</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene> and <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC ACID'>MES</scene>
|ACTIVITY=
|GENE= AR, DHTR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of human androgen receptor ligand-binding domain in complex with EM-5744'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2PNU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=ENM:'>ENM</scene>, <scene name='pdbligand=DTT:'>DTT</scene> and <scene name='pdbligand=MES:'>MES</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNU OCA].  
2PNU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNU OCA].  


==Reference==
==Reference==
Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12., Cantin L, Faucher F, Couture JF, de Jesus-Tran KP, Legrand P, Ciobanu LC, Frechette Y, Labrecque R, Singh SM, Labrie F, Breton R, J Biol Chem. 2007 Oct 19;282(42):30910-9. Epub 2007 Aug 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17711855 17711855]
Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12., Cantin L, Faucher F, Couture JF, de Jesus-Tran KP, Legrand P, Ciobanu LC, Frechette Y, Labrecque R, Singh SM, Labrie F, Breton R, J Biol Chem. 2007 Oct 19;282(42):30910-9. Epub 2007 Aug 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17711855 17711855]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: ligand binding domain]]
[[Category: ligand binding domain]]


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