2pre: Difference between revisions

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[[Image:2pre.jpg|left|200px]]<br /><applet load="2pre" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2pre.jpg|left|200px]]
caption="2pre, resolution 2.70&Aring;" />
 
'''Crystal structure of plant cysteine protease Ervatamin-C complexed with irreversible inhibitor E-64 at 2.7 A resolution'''<br />
{{Structure
|PDB= 2pre |SIZE=350|CAPTION= <scene name='initialview01'>2pre</scene>, resolution 2.70&Aring;
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+B+303'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+B+304'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+A+305'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+B+306'>AC4</scene>, <scene name='pdbsite=AC5:So4+Binding+Site+For+Residue+A+307'>AC5</scene>, <scene name='pdbsite=AC6:So4+Binding+Site+For+Residue+A+308'>AC6</scene>, <scene name='pdbsite=AC7:E64+Binding+Site+For+Residue+B+301'>AC7</scene> and <scene name='pdbsite=AC8:E64+Binding+Site+For+Residue+A+302'>AC8</scene>
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=E64:N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE'>E64</scene>
|ACTIVITY=
|GENE=
}}
 
'''Crystal structure of plant cysteine protease Ervatamin-C complexed with irreversible inhibitor E-64 at 2.7 A resolution'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2PRE is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Tabernaemontana_divaricata Tabernaemontana divaricata] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=E64:'>E64</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+B+303'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+B+304'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+A+305'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+B+306'>AC4</scene>, <scene name='pdbsite=AC5:So4+Binding+Site+For+Residue+A+307'>AC5</scene>, <scene name='pdbsite=AC6:So4+Binding+Site+For+Residue+A+308'>AC6</scene>, <scene name='pdbsite=AC7:E64+Binding+Site+For+Residue+B+301'>AC7</scene> and <scene name='pdbsite=AC8:E64+Binding+Site+For+Residue+A+302'>AC8</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRE OCA].  
2PRE is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Tabernaemontana_divaricata Tabernaemontana divaricata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRE OCA].  


==Reference==
==Reference==
Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria., Ghosh R, Chakraborty S, Chakrabarti C, Dattagupta JK, Biswas S, FEBS J. 2008 Feb;275(3):421-34. Epub 2007 Dec 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18167146 18167146]
Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria., Ghosh R, Chakraborty S, Chakrabarti C, Dattagupta JK, Biswas S, FEBS J. 2008 Feb;275(3):421-34. Epub 2007 Dec 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18167146 18167146]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Tabernaemontana divaricata]]
[[Category: Tabernaemontana divaricata]]
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[[Category: protease-inhibitor complex]]
[[Category: protease-inhibitor complex]]


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