3wpe: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of bovine TLR9 in complex with agonistic DNA1668_12mer==

~~The entry~~ 3wpe is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[3wpe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WPE FirstGlance]. <br>

~~Authors~~: ~~Ohto~~, U., ~~Tanji~~, H., ~~Shimizu~~, T.

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wpe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wpe RCSB], [http://www.ebi.ac.uk/pdbsum/3wpe PDBsum]</span></td></tr>

~~Description~~: ~~Crystal structure of bovine TLR9 in complex with agonistic DNA1668_12mer~~

</table>

[[~~Category~~: ~~Unreleased Structures~~]]

== Function ==

[[~~Category~~: ~~Tanji, H~~]]

[[http://www.uniprot.org/uniprot/TLR9_BOVIN TLR9_BOVIN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

__TOC__

</StructureSection>

[[Category: Ohto, U]]

[[Category: Shimizu, T]]

[[Category: Tanji, H]]

[[Category: Dna binding]]

[[Category: Dna binding protein-dna complex]]

[[Category: Glycosylation]]

[[Category: Innate immunity]]

[[Category: Leucine rich repeat]]

[[Category: Receptor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of bovine TLR9 in complex with agonistic DNA1668_12mer==
+<StructureSection load='3wpe' size='340' side='right' caption='[[3wpe]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
-The entry 3wpe is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3wpe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WPE FirstGlance]. <br>
-Authors: Ohto, U., Tanji, H., Shimizu, T.
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wpb|3wpb]], [[3wpc|3wpc]], [[3wpd|3wpd]], [[3wpf|3wpf]], [[3wpg|3wpg]], [[3wph|3wph]], [[3wpi|3wpi]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wpe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wpe RCSB], [http://www.ebi.ac.uk/pdbsum/3wpe PDBsum]</span></td></tr>
-Description: Crystal structure of bovine TLR9 in complex with agonistic DNA1668_12mer
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
-[[Category: Tanji, H]]
+[[http://www.uniprot.org/uniprot/TLR9_BOVIN TLR9_BOVIN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
+__TOC__
+</StructureSection>
 [[Category: Ohto, U]]
 [[Category: Shimizu, T]]
+[[Category: Tanji, H]]
+[[Category: Dna binding]]
+[[Category: Dna binding protein-dna complex]]
+[[Category: Glycosylation]]
+[[Category: Innate immunity]]
+[[Category: Leucine rich repeat]]
+[[Category: Receptor]]