4xwa: Difference between revisions
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''' | ==TMK from S.aureus in complex with the Piperidinyl Thymine class inhibitor with a C5 ethyl-amine== | ||
<StructureSection load='4xwa' size='340' side='right' caption='[[4xwa]], [[Resolution|resolution]] 1.89Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4xwa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XWA FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43N:2-(3-CHLOROPHENOXY)-6-(ETHYLAMINO)-4-[(R)-[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL](PHENYL)METHYL]BENZOIC+ACID'>43N</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xwa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xwa RCSB], [http://www.ebi.ac.uk/pdbsum/4xwa PDBsum]</span></td></tr> | |||
[[Category: | </table> | ||
[[Category: Olivier, N | == Function == | ||
[[http://www.uniprot.org/uniprot/KTHY_STAA1 KTHY_STAA1]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: DTMP kinase]] | |||
[[Category: Olivier, N B]] | |||
[[Category: Antibacterial]] | |||
[[Category: Kinase]] | |||
[[Category: Piperidine]] | |||
[[Category: Thymidine]] | |||
[[Category: Tmk]] | |||
[[Category: Transferase]] | |||
