2pvf: Difference between revisions

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[[Image:2pvf.jpg|left|200px]]<br /><applet load="2pvf" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2pvf.jpg|left|200px]]
caption="2pvf, resolution 1.8&Aring;" />
 
'''Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide'''<br />
{{Structure
|PDB= 2pvf |SIZE=350|CAPTION= <scene name='initialview01'>2pvf</scene>, resolution 1.8&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=ABG:ADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE'>ABG</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1]
|GENE= FGFR2, BEK, KSAM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2PVF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ABG:'>ABG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PVF OCA].  
2PVF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PVF OCA].  


==Reference==
==Reference==
A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases., Chen H, Ma J, Li W, Eliseenkova AV, Xu C, Neubert TA, Miller WT, Mohammadi M, Mol Cell. 2007 Sep 7;27(5):717-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17803937 17803937]
A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases., Chen H, Ma J, Li W, Eliseenkova AV, Xu C, Neubert TA, Miller WT, Mohammadi M, Mol Cell. 2007 Sep 7;27(5):717-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17803937 17803937]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: ABG]]
[[Category: ABG]]
[[Category: MG]]
[[Category: MG]]
[[Category: kinase domain fold consisting of n- and c-lobes]]
[[Category: kinase domain fold consisting of n- and c-lobe]]
[[Category: transferase]]
[[Category: transferase]]


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