UBC13 MMS2: Difference between revisions
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==Summary== | ==Summary== | ||
UBC13 is an E2 ubiquitin conjugating enzyme that can form a heterodimer with Mms2 to function as a part of the Translesion DNA Synthesis Pathway (TLS). When bound to Mms2, Ubc13 will polyubiquinate PCNA, | UBC13 is an E2 ubiquitin conjugating enzyme that can form a heterodimer with Mms2 to function as a part of the Translesion DNA Synthesis Pathway (TLS). When bound to Mms2, Ubc13 will polyubiquinate PCNA, Proliferating Cell Nuclear Antigen, a sliding clamp protein at the DNA transcription fork. UBC13-MMS2 functions to polyubiquinate PCNA following the initial monoubiquitination by Rad6-Rad18(another E2 complex). | ||
== Function == | == Function == | ||
