Sandbox Reserved 992: Difference between revisions
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One of the main causes of resistance to β-lactam drugs is caused by β-lactamases. Chemically, β-lactamases bind to β-lactams the same way β-lactams bind to PBPs. However, the β-lactamases are then able to deactivate the antimicrobial activity of the β-lactams by cleaving the β-lactam bound in the active site through a molecular process called deacylation, rendering it incapable of inhibiting the PBPs and ultimately, allowing cross-linking to occur for adequate cell wall formation. | One of the main causes of resistance to β-lactam drugs is caused by β-lactamases. Chemically, β-lactamases bind to β-lactams the same way β-lactams bind to PBPs. However, the β-lactamases are then able to deactivate the antimicrobial activity of the β-lactams by cleaving the β-lactam bound in the active site through a molecular process called deacylation, rendering it incapable of inhibiting the PBPs and ultimately, allowing cross-linking to occur for adequate cell wall formation. | ||
[[Image:Beta-lactam inhibition.png|thumb|left|Image showing mechanism performed by β-lactam antibiotic within PDB active site.]] | [[Image:Beta-lactam inhibition.png|200px|thumb|left|Image showing mechanism performed by β-lactam antibiotic within PDB active site.]] | ||
== Class C Mechanism == | == Class C Mechanism == | ||
