Z-DNA: Difference between revisions
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< | <StructureSection load='Z-DNA.pdb' size='400' side='right' scene='Z-DNA/Z-dna_new/1' caption=''> | ||
'''Z-DNA''' <scene name='Z-DNA/Z-dna_new/1'>(default scene)</scene> is a form of DNA that has a different structure from the more common <scene name='Sandbox_Z-DNA/Bdna/3'>B-DNA</scene> form.It is a left-handed double helix wherein the sugar-phosphate backbone has a zigzag pattern due to the alternate stacking of bases in [http://proteopedia.org/wiki/index.php/Syn_and_anti_nucleosides anti-conformation and syn conformation]. In Z-DNA only a minor groove is present and the major groove is absent. The residues that allow sequence-specific recognition of Z-DNA are present on the convex outer surface.<ref name = 'Rich'> PMID:12838348</ref> This DNA form is thought to play a role in the regulation of gene expression, DNA processing events and/or genetic instability.<ref name = 'Wang'>PMID:17485386</ref> | '''Z-DNA''' <scene name='Z-DNA/Z-dna_new/1'>(default scene)</scene> is a form of DNA that has a different structure from the more common <scene name='Sandbox_Z-DNA/Bdna/3'>B-DNA</scene> form.It is a left-handed double helix wherein the sugar-phosphate backbone has a zigzag pattern due to the alternate stacking of bases in [http://proteopedia.org/wiki/index.php/Syn_and_anti_nucleosides anti-conformation and syn conformation]. In Z-DNA only a minor groove is present and the major groove is absent. The residues that allow sequence-specific recognition of Z-DNA are present on the convex outer surface.<ref name = 'Rich'> PMID:12838348</ref> This DNA form is thought to play a role in the regulation of gene expression, DNA processing events and/or genetic instability.<ref name = 'Wang'>PMID:17485386</ref> | ||
</StructureSection> | |||
== Structure == | == Structure == | ||
<applet load='2acj' size='280' frame='true' align='left' caption=' B-Z DNA junction (PDB entry [[2acj]]) ' scene ='Sandbox_Z-DNA/B-z/7' /> | <applet load='2acj' size='280' frame='true' align='left' caption=' B-Z DNA junction (PDB entry [[2acj]]) ' scene ='Sandbox_Z-DNA/B-z/7' /> | ||
