UBC13 MMS2: Difference between revisions

Ubc13 functions as a heterodimer with Mms2, a structurally similar protein to Ubc13 that lacks the catalytic cysteine residue in the active site.  The Ubc13 E2 complex with Mms2 functions primarily to enhance DNA repair from double stranded breaks.  Mms2 bound to Ubc13 helps orient the ubiquitin molecule for proper ubiquitination of the K63 residue.  Mms2 is considered a UEV protein (Ubiquitin-conjugating Enzyme Variant), because it lacks the catalytic cysteine residue necessary for proper thioester formation.