Sandbox Reserved 992: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Aron Rottier (talk | contribs) No edit summary |
No edit summary |
||
| Line 32: | Line 32: | ||
</ref> | </ref> | ||
One of the main causes of resistance to β-lactam drugs is caused by β-lactamases. Chemically, β-lactamases bind to β-lactams the same way β-lactams bind to PBPs. However, the β-lactamases are then able to deactivate the antimicrobial activity of the β-lactams by cleaving the β-lactam bound in the active site through a molecular process called deacylation, rendering it incapable of inhibiting the PBPs and ultimately, allowing cross-linking to occur for adequate cell wall formation. | One of the main causes of resistance to β-lactam drugs is caused by β-lactamases. Chemically, β-lactamases bind to β-lactams the same way β-lactams bind to PBPs. However, the β-lactamases are then able to deactivate the antimicrobial activity of the β-lactams by cleaving the β-lactam bound in the active site through a molecular process called [http://en.m.wikipedia.org/wiki/Acetylation deacylation], rendering it incapable of inhibiting the PBPs and ultimately, allowing cross-linking to occur for adequate cell wall formation. | ||
[[Image:Beta-lactam inhibition.png|400px|thumb|left|Image showing mechanism performed by β-lactam antibiotic within PDB active site.]] | [[Image:Beta-lactam inhibition.png|400px|thumb|left|Image showing mechanism performed by β-lactam antibiotic within PDB [http://en.m.wikipedia.org/wiki/Active_site active site].]] | ||
== Class C Mechanism == | == Class C Mechanism == | ||
