Sandbox Reserved 987: Difference between revisions
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== Mutations == | == Mutations == | ||
The wild-type cocaine esterase is not stable at physiological temperature, which poses a problem for its use as a pharmaceutical drug. | The wild-type cocaine esterase is not stable at physiological temperature, which poses a problem for its use as a pharmaceutical drug. Mutations have been conducted in order to increase its thermostability. In vivo testing showed the wild-type having a 11min half-life. A mutant having its threonine swapped for a arginine at position 172 was found to last 9 times as long and a mutant that further had its glycine swapped for a glutamine was found to last 24 times as long (~4hr 20min) | ||
== Medical Relevance == | == Medical Relevance == | ||
