4xui: Difference between revisions
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''' | ==Crystal structure analysis of cruzain bound to the no-covalent analog of WRR-483 (WRR-669)== | ||
<StructureSection load='4xui' size='340' side='right' caption='[[4xui]], [[Resolution|resolution]] 2.51Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4xui]] is a 3 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4pi4 4pi4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XUI FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2VC:N-[(2S)-5-(CARBAMIMIDAMIDOOXY)-1-OXO-1-{[(1E,3S)-5-PHENYL-1-(PYRIMIDIN-2-YLSULFONYL)PENT-1-EN-3-YL]AMINO}PENTAN-2-YL]-4-METHYLPIPERAZINE-1-CARBOXAMIDE'>2VC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pi3|4pi3]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cruzipain Cruzipain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.51 3.4.22.51] </span></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xui OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xui RCSB], [http://www.ebi.ac.uk/pdbsum/4xui PDBsum]</span></td></tr> | ||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cruzipain]] | |||
[[Category: McKerrow, J H]] | |||
[[Category: Tochowicz, A]] | [[Category: Tochowicz, A]] | ||
[[Category: Chagas disease]] | |||
[[Category: Covalent reversible inhibitor]] | |||
[[Category: Cruzain]] | |||
[[Category: Cysteine protease]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Trypanosoma cruzi]] | |||
[[Category: Vinyl sulfone analog]] | |||
Revision as of 11:43, 11 March 2015
Crystal structure analysis of cruzain bound to the no-covalent analog of WRR-483 (WRR-669)
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