4p3o: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 2==

~~The entry~~ 4p3o is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4p3o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3O OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P3O FirstGlance].

~~Authors~~: ~~Fang~~, P., Yu, X., ~~Chen~~, K., ~~Chen~~, X., ~~Guo~~, M.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=2CR:(1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-CYANO-8,16-DIHYDROXY-9,11,13,15-TETRAMETHYL-18-OXOOXACYCLOOCTADECA-4,6-DIEN-2-YL]CYCLOPENTANECARBOXYLIC+ACID'>2CR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4p3n|4p3n]], [[4p3p|4p3p]]</td></tr>

~~Description~~: ~~Structural Basis for Full~~-~~Spectrum Inhibition of Threonyl~~-tRNA ~~Synthetase by Borrelidin 2~~

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p3o RCSB], [http://www.ebi.ac.uk/pdbsum/4p3o PDBsum]</td></tr>

[[Category: ~~Yu, X~~]]

</table>

[[Category: ~~Guo~~, M]]

== Function ==

[[http://www.uniprot.org/uniprot/SYT_ECOLI SYT_ECOLI]] ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA.[HAMAP-Rule:MF_00184]

__TOC__

</StructureSection>

[[Category: Threonine--tRNA ligase]]

[[Category: Chen, K]]

[[Category: Chen, X]]

[[Category: Fang, P]]

[[Category: ~~Chen~~, K]]

[[Category: Guo, M]]

[[Category: Yu, X]]

[[Category: Inhibitor]]

[[Category: Synthetase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 2==
+<StructureSection load='4p3o' size='340' side='right' caption='[[4p3o]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-The entry 4p3o is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4p3o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P3O FirstGlance]. <br>
-Authors: Fang, P., Yu, X., Chen, K., Chen, X., Guo, M.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CR:(1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-CYANO-8,16-DIHYDROXY-9,11,13,15-TETRAMETHYL-18-OXOOXACYCLOOCTADECA-4,6-DIEN-2-YL]CYCLOPENTANECARBOXYLIC+ACID'>2CR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p3n|4p3n]], [[4p3p|4p3p]]</td></tr>
-Description: Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 2
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p3o RCSB], [http://www.ebi.ac.uk/pdbsum/4p3o PDBsum]</span></td></tr>
-[[Category: Yu, X]]
+</table>
-[[Category: Guo, M]]
+== Function ==
+[[http://www.uniprot.org/uniprot/SYT_ECOLI SYT_ECOLI]] ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA.[HAMAP-Rule:MF_00184]
+__TOC__
+</StructureSection>
+[[Category: Threonine--tRNA ligase]]
+[[Category: Chen, K]]
 [[Category: Chen, X]]
 [[Category: Fang, P]]
-[[Category: Chen, K]]
+[[Category: Guo, M]]
+[[Category: Yu, X]]
+[[Category: Inhibitor]]
+[[Category: Synthetase]]