4rda: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==X-RAY STRUCTURE OF THE AMYLOID PRECURSOR PROTEIN-LIKE PROTEIN 1 (APLP1) E2 DOMAIN IN COMPLEX WITH A HEPARIN DODECASACCHARIDE==

~~The entry~~ 4rda is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4rda]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RDA OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RDA FirstGlance].

~~Authors~~: ~~Dahms~~, S.O., ~~Than~~, M.E.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=UAP:4-DEOXY-2-O-SULFO-ALPHA-L-THREO-HEX-4-ENOPYRANURONIC+ACID'>UAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4rd9|4rd9]]</td></tr>

~~Description: X-ray structure of a heparan sulfate binding protein 2~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rda RCSB], [http://www.ebi.ac.uk/pdbsum/4rda PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

[[Category: Dahms, S.O]]

== Function ==

[[Category: Than, M.E]]

[[http://www.uniprot.org/uniprot/APLP1_HUMAN APLP1_HUMAN]] May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.

__TOC__

</StructureSection>

[[Category: Dahms, S O]]

[[Category: Than, M E]]

[[Category: Heparan sulfate binding]]

[[Category: Sugar binding protein]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==X-RAY STRUCTURE OF THE AMYLOID PRECURSOR PROTEIN-LIKE PROTEIN 1 (APLP1) E2 DOMAIN IN COMPLEX WITH A HEPARIN DODECASACCHARIDE==
+<StructureSection load='4rda' size='340' side='right' caption='[[4rda]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-The entry 4rda is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4rda]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RDA FirstGlance]. <br>
-Authors: Dahms, S.O., Than, M.E.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UAP:4-DEOXY-2-O-SULFO-ALPHA-L-THREO-HEX-4-ENOPYRANURONIC+ACID'>UAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rd9|4rd9]]</td></tr>
-Description: X-ray structure of a heparan sulfate binding protein 2
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rda OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rda RCSB], [http://www.ebi.ac.uk/pdbsum/4rda PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Dahms, S.O]]
+== Function ==
-[[Category: Than, M.E]]
+[[http://www.uniprot.org/uniprot/APLP1_HUMAN APLP1_HUMAN]] May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.  The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
+__TOC__
+</StructureSection>
+[[Category: Dahms, S O]]
+[[Category: Than, M E]]
+[[Category: Heparan sulfate binding]]
+[[Category: Sugar binding protein]]