4wzi: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of crosslink stabilized long-form PDE4B==

~~The entry~~ 4wzi is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4wzi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WZI OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WZI FirstGlance].

~~Authors~~: ~~Cedervall~~, P., ~~Pandit~~, J.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4x0f|4x0f]]</td></tr>

~~Description~~: ~~Crystal structure~~ of ~~crosslink stabilized long~~-~~form PDE4B~~

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wzi RCSB], [http://www.ebi.ac.uk/pdbsum/4wzi PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>

== References ==

__TOC__

</StructureSection>

[[Category: 3',5'-cyclic-AMP phosphodiesterase]]

[[Category: Cedervall, P]]

[[Category: Pandit, J]]

[[Category: Hydrolase]]

[[Category: Phosphodiesterase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of crosslink stabilized long-form PDE4B==
+<StructureSection load='4wzi' size='340' side='right' caption='[[4wzi]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
-The entry 4wzi is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4wzi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WZI FirstGlance]. <br>
-Authors: Cedervall, P., Pandit, J.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x0f|4x0f]]</td></tr>
-Description: Crystal structure of crosslink stabilized long-form PDE4B
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wzi RCSB], [http://www.ebi.ac.uk/pdbsum/4wzi PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: 3',5'-cyclic-AMP phosphodiesterase]]
 [[Category: Cedervall, P]]
 [[Category: Pandit, J]]
+[[Category: Hydrolase]]
+[[Category: Phosphodiesterase]]