2qsz: Difference between revisions
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[[Image:2qsz.jpg|left|200px]] | [[Image:2qsz.jpg|left|200px]] | ||
'''Human nicotinamide riboside kinase 1 in complex with nicotinamide mononucleotide''' | {{Structure | ||
|PDB= 2qsz |SIZE=350|CAPTION= <scene name='initialview01'>2qsz</scene>, resolution 1.900Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene> and <scene name='pdbligand=UNX:UNKNOWN ATOM OR ION'>UNX</scene> | |||
|ACTIVITY= | |||
|GENE= NRK1, C9orf95 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Human nicotinamide riboside kinase 1 in complex with nicotinamide mononucleotide''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2QSZ is a [ | 2QSZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QSZ OCA]. | ||
==Reference== | ==Reference== | ||
Nicotinamide riboside kinase structures reveal new pathways to NAD+., Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C, PLoS Biol. 2007 Oct 2;5(10):e263. PMID:[http:// | Nicotinamide riboside kinase structures reveal new pathways to NAD+., Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C, PLoS Biol. 2007 Oct 2;5(10):e263. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17914902 17914902] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: pyridine nucleotide biosynthesis]] | [[Category: pyridine nucleotide biosynthesis]] | ||
[[Category: sgc]] | [[Category: sgc]] | ||
[[Category: structural | [[Category: structural genomic]] | ||
[[Category: structural genomics consortium]] | [[Category: structural genomics consortium]] | ||
[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:29:21 2008'' | ||
Revision as of 16:29, 20 March 2008
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| 2qsz, resolution 1.900Å | |||||||||||||
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| Ligands: | PO4, CL, NMN and UNX | ||||||||||||
| Gene: | NRK1, C9orf95 (Homo sapiens) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Human nicotinamide riboside kinase 1 in complex with nicotinamide mononucleotide
Overview
The eukaryotic nicotinamide riboside kinase (Nrk) pathway, which is induced in response to nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to nicotinamide adenine dinucleotide (NAD+) by phosphorylation and adenylylation. Crystal structures of human Nrk1 bound to nucleoside and nucleotide substrates and products revealed an enzyme structurally similar to Rossmann fold metabolite kinases and allowed the identification of active site residues, which were shown to be essential for human Nrk1 and Nrk2 activity in vivo. Although the structures account for the 500-fold discrimination between nicotinamide riboside and pyrimidine nucleosides, no enzyme feature was identified to recognize the distinctive carboxamide group of nicotinamide riboside. Indeed, nicotinic acid riboside is a specific substrate of human Nrk enzymes and is utilized in yeast in a novel biosynthetic pathway that depends on Nrk and NAD+ synthetase. Additionally, nicotinic acid riboside is utilized in vivo by Urh1, Pnp1, and Preiss-Handler salvage. Thus, crystal structures of Nrk1 led to the identification of new pathways to NAD+.
About this Structure
2QSZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Nicotinamide riboside kinase structures reveal new pathways to NAD+., Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C, PLoS Biol. 2007 Oct 2;5(10):e263. PMID:17914902
Page seeded by OCA on Thu Mar 20 18:29:21 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Homo sapiens
- Single protein
- Arrowsmith, C H.
- Bochkarev, A.
- Brenner, C.
- Edwards, A M.
- Landry, R.
- Nedyalkova, L.
- Park, H.
- Rabeh, W M.
- SGC, Structural Genomics Consortium.
- Sundstrom, M.
- Tempel, W.
- Weigelt, J.
- CL
- NMN
- PO4
- UNX
- Adp
- Alternative splicing
- Atp-binding
- Nad biosynthesis
- Nad+
- Nicotinamide riboside
- Nicotinamide riboside kinase activity
- Nicotinic acid riboside kinase activity
- Non-protein kinase
- Nrk1
- Nucleotide-binding
- Pyridine nucleotide biosynthesis
- Sgc
- Structural genomic
- Structural genomics consortium
- Transferase
